Abstract
Roll-to-roll Manufacturing of Lab-on-a-Foil Chips for IVD applications
Pakapreud Khumwan, Visiting Scientist, JOANNEUM RESEARCH Forschungsgesellschaft mbH
Lateral flow tests have become a valuable tool in combating the spread of the SARS-CoV-2 virus throughout the COVID-19 pandemic owing to their simplicity and ease of use that altogether permit great access by the general public. Despite their relatively affordable price for the consumers and low cost of production for the manufacturers, paper-based fluidics that underpin nearly all lateral flow tests still suffer from a critical lack of scalability to meet the high demand of testing and versatility for other bioassay applications. To address this existing need, we leverage the roll-to-roll UV nanoimprinting lithography (UV NIL) for the high-throughput production of foil-based microfluidic chips whose biological relevance has been showcased through a semi-quantitative serology test for COVID-19 antibody detection. With respect to conventional fabrication techniques for microfluidic devices, UV NIL offers unmatched competitive advantages, particularly speed, seamless handling, and the ability to chemically adjust the material properties required by certain applications. This presentation serves to provide a brief overview of the UV NIL manufacturing process, and how we implemented it along with other processes on the roll-to-roll system to ultimately unleash its power for the development of modern microfluidic chips.
Pakapreud Khumwan, Visiting Scientist, JOANNEUM RESEARCH Forschungsgesellschaft mbH
Pak earned a doctoral degree in Bioengineering from the University of Washington in 2018 from his development of a real-time blood typing test on the silicon photonic microring resonator upon which a core technology of a point-of-care blood typing startup in Seattle is based. Prior to joining Joanneum Research Materials as a visiting scientist, he held a position as a researcher at the National Center for Generic Engineering and Biotechnology (BIOTEC) in Thailand focusing on the democratization of diagnostic tests based on the integration of isothermal amplification assay with various affordable sensing modalities. He is currently a member of the Sensors and Functional Printing team where he dedicates his efforts to the biofunctionalization of foil-based sensors and high-throughput roll-to-roll microarray spotting.
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